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KMID : 0351619680090010025
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Kyungpook Medical Journal
1968 Volume.9 No. 1 p.25 ~ p.42
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Studies on the Sugar Absorption and Morphology of Small Intestine of Rat Administered High Doses of Neomycin and the Effect of Prednisolone on the Neomycin-Induced Changes
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Abstract
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An experimental study was performed on rats to investigate the absorptive function of sugars and Morphology of the small intestine of rate adminlistered high doses of reomycin and the effect of prednisolone on the neomycin-induced changes.
The Control group received ?? ml. of sterile normal saline by intragastric instillation daily for 21 days, neomycin group received neomycin sulfate at a dose of 2 gm/kg daily for 21 days by the same manner as in control group and neomycin+prednisolone group received prednisolone 2mg/kg besides neomycin of the above doses.
For the sugar absorption study, 1ml. of 25% d-xylose or 25% glulose were introduced into the duodenum directly through a gastric tube as described by Small et al. Morphologic changes of the villi were observed by measuring the villous height, breadth and the thickness of the nonvillous mucosa as described by Roy-Choudhury et al. For this study, four specimens were taken from the sites near the pyloric ring, 12 cm distally from the pyloric ring, 20cm proximally from the terminal ileum and terminal ileum.
The results obtained were as follows:
1) D-xylose absorption was decreased in neomycin group and was increased in neomycin+prednisolone group.
2) Clucose absorption was increased in both neomycin and neomycin+prednisolone groups compared with the control group and it was greater in neomycin+prednisolone group than in neomycin group.
3) The villi are flattened only inconstantly in neomycin group, but in neomycin+prednisolone group in the villous height was higher inaverage and the scattergram and histogram showed shifting to the higher side. This suggests that prednisolone may prevent the noxious effect of neomycin to the mucosa of the small intestine.
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